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Drinking impairs success rates

Issue 03: 10 Feb 2003

Source: Fertility and Sterility 2003; 79: 330-9

Success rates for assisted reproductive technologies could be improved by encouraging both partners to drink less alcohol, according to new study findings.

Researchers at the University of California, in San Diego, USA, found that alcohol consumption by men and women can significantly influence the success rates of IVF and gamete intra-fallopian transfer (GIFT). They report: "Female drinking affected oocyte retrieval, pregnancy, and miscarriage rates; male drinking affected miscarriage and live birth rates."

The effects of alcohol intake

The researchers investigated 221 couples with female infertility, recruited from seven clinics in Southern California. Both partners completed questionnaires on alcohol intake at several stages through the assisted reproduction process.

One drink was defined as an alcohol intake of 12 g—the average content of a typical serving of beer, wine, liquor or mixed drinks. After analysis of the results, the researchers found that alcohol consumption by women was associated with:

* A 13 percent decrease in the number of eggs aspirated, for every extra drink consumed per day 1 year before the IVF/GIFT attempt.

* A 2.86 times increased risk of not achieving pregnancy, for every extra drink consumed per day 1 month prior to the attempt.

* A 2.21 times increased risk of miscarriage, for every extra drink consumed per day 1 week before the procedure.

Alcohol consumption by men was associated with:

* An increased risk of miscarriage: ranging from a 2.7 times increased risk for every extra drink consumed per day in the month before the IVF or GIFT attempt, to a 38.04 times increased risk for every extra drink consumed per day during the attempt.

* An increased risk of not achieving a live birth: ranging from a 2.28 times increased risk for every extra drink consumed per day the month before the attempt, to an 8.32 times increased risk for every extra drink consumed per day in the week before sperm collection.

Call to modify drinking habits

The San Diego research team stresses that the findings are preliminary, but suggests: "Because alcohol use is ubiquitous, modifying drinking habits may increase ART success rates and potentially impact couples using natural reproduction. If these findings are replicated in future studies, clinicians should recommend that couples abstain from alcohol consumption >= 1 month before the attempt, to maximize the effectiveness and success of the IVF or GIFT procedures."

The researchers also note: "Although very few woman reported drinking after the procedure and during the pregnancy, a high percentage of men drank alcohol for all the time periods, suggesting a misconception that men's alcohol use does not affect pregnancy rates."

Hanne M.

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