Rapamycin for nedsatt fertilitet

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Det er ein del kvinner som freistar bruka rapamycin for nedsatt fertilitet, nokre kvinner som har nådd overgangsalderen har òg fått tilbake mensen. Rett no er det ein større studie på gong. Det vert spanande å sjå kva han viser. I framtida er det kanskje mogeleg å få barn langt ut i 5]-åra.

https://www.rapamycin.news/t/women-taking-rapamycin-for-enhanced-fertility-menopause-prevention/909

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Immunsupprimerende legemiddel?!  Nei, vet du hva

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At man får tilbake mensen betyr ikke at eggene har god nok kvalitet til å blir befruktet eller til å faktisk bli til et foster som er levedyktig. 

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Fame skrev (13 minutter siden):

Immunsupprimerende legemiddel?!  Nei, vet du hva

Called rapamycin, the medication is used in human transplant patients to prevent organ rejection. But studies in yeast, worms and mice show that low doses can extend lifespan by up to 25%. Rapamycin also delays age-related maladies such as cognitive decline and cancer, and boosts heart health in mice.

 

Dr. Kate Creevy, chief veterinary officer for the project, is optimistic it might do the same for dogs. In one small trial, dogs who got the drug showed improved heart function. In another, owners said their dogs seemed more active.

Now, the team is recruiting 500 senior dogs for a year of treatment and two years of follow-up. Half the dogs will get rapamycin, and half will get a placebo. Neither owners nor scientists will know which until the end.

https://www.seattletimes.com/pacific-nw-magazine/the-dog-aging-project-digs-deeper-than-ever-to-help-our-best-friends-live-better-longer-and-the-findings-could-help-us-too/

 

Kaeberlein says the drug actually works more as an immune modulator. In aging, the immune system is often activated against normal tissue and is inactive toward invaders it should see. “Rapamycin appears to restore that balance,” he says.

https://www.wsj.com/articles/can-you-fight-aging-scientists-are-testing-drugs-to-help-11641913275

Now, reporting in Science Translational Medicine, Mannick and colleagues show that treatment with a low dose of a combination of drugs that inhibit TORC1, a multi-protein complex that contains mTOR, can enhance responses to flu vaccination and decrease overall infection rates in elderly humans.

https://www.nature.com/articles/s41577-018-0052-0

 

 

Anonymkode: 4b4ca...3e7

[AnonymBruker]

By thoroughly comparing these various studies, the researchers found that dietary restriction slightly but significantly increased the risk of pathogen infection, while rapamycin treatment significantly decreased it, particularly in secondary infections.

https://www.lifespan.io/news/rapamycin-not-dietary-restriction-fights-infection-in-mice?fbclid=IwAR1GaTSBx35MEbzKBbb5PS-WMzr0YU_nY_HIohiZbZ0pQgJ1YKxfc9Dkbdk

Anonymkode: 4b4ca...3e7